v

您的位置:VeryCD图书其它图书

图书资源事务区


《生物化学毒物学原理毒理学第四版》(Principles of Biochemical Toxicology, Fourth Edition)(John A. Timbrell)文字版、第四版、高清版[PDF]

  • 状态: 精华资源
  • 摘要:
    发行时间2008年11月18日
    语言英文
  • 时间: 2009/09/25 21:05:30 发布 | 2009/09/26 08:29:53 更新
  • 分类: 图书  其它图书 

superain

精华资源: 34

全部资源: 37

相关: 分享到新浪微博   转播到腾讯微博   分享到开心网   分享到人人   分享到QQ空间   订阅本资源RSS更新   美味书签  subtitle
该内容尚未提供权利证明,无法提供下载。
中文名生物化学毒物学原理毒理学第四版
原名Principles of Biochemical Toxicology, Fourth Edition
资源格式PDF
版本文字版、第四版、高清版
发行时间2008年11月18日
地区大陆
语言英文
简介

IPB Image
◎原  名 Principles of Biochemical Toxicology, Fourth Edition
◎出版时间 2008年11月18日
◎国  家 美国
◎类  别 教育科技-医学
◎版  本 第四版
◎语  言 英文
◎文件格式 PDF
◎文件大小 11.7MB
◎页  码 453页
◎作  者 John A. Timbrell

◎内容简介:

  这在该领域处于领先地位的教科书对毒性机制进行了研究,特别是在分子和因子方面对毒性研究起到了决定性的影响。新版本更新,以反映到生物化学基础上的最新研究和对药物的不利影响,环境污染,职业危害日益关注。《生化毒理学原理第四版》彻底解释剂量反应关系,处置和代谢,以及外国化合物的毒性反应,并列出了详细的例子,对在毒性机制方面学生首次更容易遇到的问题做出明确的讲解。内容全面、简洁、明快,内容包括概要部分,问题和标准答案,并完全的修正了原作品,作为一个不可或缺的辅助学习和教学服务。

This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards. Principles of Biochemical Toxicology, Fourth Edition thoroughly explains dose-response relationships, disposition and metabolism, and toxic responses to foreign compounds, and presents detailed examples to make the mechanisms of toxicity more accessible to students encountering the subject for the first time. Comprehensive in scope with a clear and concise approach, the text includes summary sections, questions and model answers, and thoroughly revised artwork that serves as an essential aid to learning and teaching. New to the Fourth Edition:

reorganized sections that cover basic principles followed by sections on different types of toxicity extensive use of examples throughout and numerous explanatory diagrams
new material on risk assessment, export systems, oxidative stress, Thalidomide, Tamoxifen and asbestos proliferators, domoic acid, bone marrow (benzene), heart (adriamycin), blood (primaquine), biomarkers, cytochrome P450 and other enzymes, receptor mediated effects, endocrine disruption, ethanol, botox, arsenic, and more
questions with answers for each chapter for review and self-checking
expanded and updated chapter bibliographiesd

◎内容截图
IPB Image



目录

Preface v
1. Introduction 1
1.1 Background 1
1.2 Scope 2
1.3 Biochemical Aspects of Toxicology 2
Summary 4
Review Questions 4
Bibliography 5
2. Fundamentals of Toxicology and Dose-Response Relationships 7
2.1 Introduction 7
2.2 Biomarkers 7
2.3 Criteria of Toxicity 8
2.4 New Technologies 11
2.5 Evaluation of Toxicity 11
2.6 Interactions 14
2.7 Dose Response 16
2.8 Measurement of Dose-Response Relationships 20
2.9 Linear Dose Response 25
2.10 Hormesis 26
2.11 Hazard and Risk Assessment 27
2.12 Duration and Frequency of Exposure and Effect 31
Summary 32
Review Questions 32
References 32
Bibliography 33
3. Factors Affecting Toxic Responses: Disposition 35
3.1 Introduction 35
3.2 Absorption 35
3.3 Sites of Absorption 43
3.4 Distribution 53
3.5 Excretion 66
Summary 71
Review Questions 72
References 73
Bibliography 73
4. Factors Affecting Toxic Responses: Metabolism 75
4.1 Introduction 75
4.2 Types of Metabolic Change 76
4.3 Phase 1 Reactions 77
4.4 Phase 2 Reactions 102
4.5 General Summary Points 115
4.6 Control of Metabolism 116
……
7. Biochemical Mechanisms of Toxicity: Specific Examples 293
7.1 Chemical Carcinogenesis 293
7.2 Tissue Lesions: Liver Necrosis 308
7.3 Tissue Lesions: Kidney Damage 327
7.4 Tissue Lesions: Lung Damage 335
7.5 Neurotoxicity 339
7.6 Exaggerated and Unwanted Pharmacological Effects 345
7.7 Physiological Effects 354
7.8 Biochemical Effects: Lethal Synthesis and Incorporation 358
7.9 Biochemical Effects: Interaction with Specific Protein Receptors 361
7.10 Teratogenesis 367
7.11 Immunotoxicity 373
7.12 Multi-Organ Toxicity 383
7.13 Multi-Organ Toxicity: Metals 386
Summary 392
Review Questions 401
References 402
Bibliography 403
Glossary 409
Answers to review questions 423
Index 439

正在读取……

这里是其它用户补充的资源(我也要补充):

暂无补充资源
正在加载,请稍等...

点击查看所有28网友评论

 

(?) [公告]留口水、评论相关规则 | [活动]每日签到 轻松领取电驴经验

    小贴士:
  1. 类似“顶”、“沙发”之类没有营养的文字,对勤劳贡献的楼主来说是令人沮丧的反馈信息。
  2. 提问之前请再仔细看一遍楼主的说明,或许是您遗漏了。
  3. 勿催片。请相信驴友们对分享是富有激情的,如果确有更新版本,您一定能搜索到。
  4. 请勿到处挖坑绊人、招贴广告。既占空间让人厌烦,又没人会搭理,于人于己都无利。
  5. 如果您发现自己的评论不见了,请参考以上4条。